Big alert for anyone who is still using IE: A loophole has been discovered that allows hackers to take over your computer and steal passwords. Security experts actually recommend using another browser, to protect yourself against this. Read the article here
Even for those who are already using some other browser, caution still needs to be taken because many programs actually use an embedded IE browser. This means you'll still get hit if a program you're using loads an infected web page. There's really no defense against this, other than to "be careful", as Microsoft themselves say.
Really, those who haven't should give Google Chrome a try.